What is diabetes?
Diabetes is a condition that happens when your blood sugar (glucose) is too high. It develops when your pancreas doesn’t make enough insulin or any at all, or when your body isn’t responding to the effects of insulin properly. Diabetes affects people of all ages. Most forms of diabetes are chronic (lifelong), and all forms are manageable with medications and/or lifestyle changes.
Glucose (sugar) mainly comes from carbohydrates in your food and drinks. It’s your body’s go-to source of energy. Your blood carries glucose to all your body’s cells to use for energy.
When glucose is in your bloodstream, it needs help — a “key” — to reach its final destination. This key is insulin (a hormone). If your pancreas isn’t making enough insulin or your body isn’t using it properly, glucose builds up in your bloodstream, causing high blood sugar (hyperglycemia).
Over time, having consistently high blood glucose can cause health problems, such as heart disease, nerve damage and eye issues.
Over time, having consistently high blood glucose can cause health problems, such as heart disease, nerve damage and eye issues.
What are the types of diabetes?
There are several types of diabetes. The most common forms include:
Type 2 diabetes:
With this type, your body doesn’t make enough insulin and/or your body’s cells don’t respond normally to the insulin (insulin resistance). This is the most common type of diabetes. It mainly affects adults, but children can have it as well. Prediabetes: This type is the stage before Type 2 diabetes. Your blood glucose levels are higher than normal but not high enough to be officially diagnosed with Type 2 diabetes.Type 1 diabetes:
This type is an autoimmune disease in which your immune system attacks and destroys insulin-producing cells in your pancreas for unknown reasons. Up to 10% of people who have diabetes have Type 1. It’s usually diagnosed in children and young adults, but it can develop at any age.Symptoms of diabetes include:
- Increased thirst (polydipsia) and dry mouth.
- Frequent urination.
- Fatigue
- Blurred vision.
- Unexplained weight loss.
- Numbness or tingling in your hands or feet.
- Slow-healing sores or cuts.
- Frequent skin and/or vaginal yeast infections.
Causes of diabetes include:
Insulin resistance:
Type 2 diabetes mainly results from insulin resistance. Insulin resistance happens when cells in your muscles, fat and liver don’t respond as they should to insulin. Several factors and conditions contribute to varying degrees of insulin resistance, including obesity, lack of physical activity, diet, hormonal imbalances, genetics and certain medications.Autoimmune disease:
Type 1 diabetes and LADA happen when your immune system attacks the insulin-producing cells in your pancreas.Hormonal imbalances:
During pregnancy, the placenta releases hormones that cause insulin resistance. You may develop gestational diabetes if your pancreas can’t produce enough insulin to overcome the insulin resistance. Other hormone-related conditions like acromegaly and Cushing syndrome can also cause Type 2 diabetes.Pancreatic Damage:
Physical damage to your pancreas — from a condition, surgery or injury — can impact its ability to make insulin, resulting in Type 3c diabetes. Genetic mutations: Certain genetic mutations can cause MODY and neonatal diabetes. Long-term use of certain medications can also lead to Type 2 diabetes, including HIV/AIDS medications and corticosteroids.Acute diabetes complications that can be life-threatening include:
Hyperosmolar hyperglycemic state (HHS):
This complication mainly affects people with Type 2 diabetes. It happens when your blood sugar levels are very high (over 600 milligrams per deciliter or mg/dL) for a long period, leading to severe dehydration and confusion. It requires immediate medical treatment.Diabetes-related ketoacidosis (DKA):
This complication mainly affects people with Type 1 diabetes or undiagnosed T1D. It happens when your body doesn’t have enough insulin. If your body doesn’t have insulin, it can’t use glucose for energy, so it breaks down fat instead. This process eventually releases substances called ketones, which turn your blood acidic. This causes labored breathing, vomiting and loss of consciousness. DKA requires immediate medical treatment.Severe low blood sugar (hypoglycemia):
Hypoglycemia happens when your blood sugar level drops below the range that’s healthy for you. Severe hypoglycemia is very low blood sugar. It mainly affects people with diabetes who use insulin. Signs include blurred or double vision, clumsiness, disorientation and seizures. It requires treatment with emergency glucagon and/or medical intervention.Long-term diabetes complications.
Blood glucose levels that remain high for too long can damage your body’s tissues and organs. This is mainly due to damage to your blood vessels and nerves, which support your body’s tissues.Cardiovascular (heart and blood vessel) issues are the most common type of long-term diabetes complication. They include:
- Coronary artery disease.
- Heart attack.
- Stroke.
- Atherosclerosis.
Nerve damage (neuropathy), which can cause numbness, tingling and/or pain. Nephropathy, which can lead to kidney failure or the need for dialysis or transplant. Retinopathy, which can lead to blindness.
- Diabetes-related foot conditions.
- Skin infections.
- Amputations
- Sexual dysfunction due to nerve and blood vessel damage, such as erectile dysfunction or vaginal dryness.
- Gastroparesis.
- Hearing loss.
- Oral health issues, such as gum (periodontal) disease.